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1 Effect of semaglutide treatment or placebo on waist circumference from baseline to week 104 by subgroups

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Upon receptor activation, IGF1R autophosphorylates on tyrosine residues 1131, 1135, and 1136 in the activation loop

CEF-treated animals (200 mg/kg/d) for 14-18 days also showed a marked decrement in immobility in the forced swim and tail suspension tests