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10.1523/jneurosci.22-15-06537.2002 J

A.ChengA

10.1371/journal.pone.0066830 75 MaterazziS.FusiC.BenemeiS.PedrettiP.PatacchiniR.NiliusB.et al

It can be observed that bioactive compounds are able to suppress MITF or TYR activity by either binding to transcription factors directly or by inhibiting melanogenic pathways upstream, including that of cAMP/PKA, ERK, Wnt/-catenin and MAPK