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Heteroaryl groups include, but are not limited to, pyrrolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, thiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiophenyl, benzothiophenyl, furanyl, benzofuranyl, indolyl, azaindolyl (pyrrolopyridinyl), indazolyl, benzimidazolyl, pyrazolopyridinyl, triazolopyridinyl, benzotriazolyl, benzoxazolyl, benzothiazolyl, imidazopyridinyl, isoxazolopyridinylxanthinyl, guaninyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, quinoxaliny halo or halogen is intended to include F, Cl, Br, and I

However, substituting the ethyl ester with an amide group, as in SRS9-11 (EC50 = 950 nM), resulted in a notable reduction in activity, though this finding was later contradicted by Hofmans et al

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Tirzepatide has been studied across a wide range of body weights (from 40 kg to over 200 kg), with only minor differences in exposure that are not clinically significant enough to warrant dose modifications