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Next, we disrupted the nuclear localization sequence in TDP-43 (TDP-43 NLSmut ) to mislocalize TDP-43 to the cytoplasm and found that in response to sodium arsenite, TDP-43 NLSmut blocks SUMOylation indicating that nuclear localization is essential for TDP-43 SUMOylation (Fig

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When the pH drops below their isoelectric point, their net charge becomes positive, allowing electrostatic interactions with negatively charged polysaccharides and making them highly appropriate for immobilization applications (285)