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Se (as an Se dimer) has also been incorporated into the HDAC inhibitor Vorinostat (suberoylanilide hydroxamic acid) to form SelSA-1, which binds to the catalytic centre of multiple HDAC enzymes and has been found to be more effective than Vorinostat in inhibiting HDAC activity [72]

Altogether, the regulation of the HPA axis, plasma CBG levels, and tissue expression of 11-HSD enzymes ultimately determine cortisol bioavailability, which, in conjunction with tissue-specific GR expression and function, dictates the specific biological responses

doi: 10.1038/s41467-018-06103-6 Summary Keywords biofilm, Candida albicans , drug resistance, host immunity, novel antifungal therapy Citation Wu J, Jiang C, Wang H, Chen T, Chen X and Da W (2026) The pathogenicity and future treatment strategies of Candida albicans

doi: 10.1038/s41572-021-00327-5 129 AkiyamaMOhtsukiSBerryGJLiangDHGoronzyJJWeyandCM