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Despite the obvious biologic plausibility, the lack of consistent epidemiological evidence might be due to methodological issues including lack of cohort follow-up time into older adulthood (when lung cancer usually becomes clinically manifest), small sample sizes, selection and recall biases, and lack of adjustment for tobacco use in the statistical modeling

[23] Jew EK, Dougill AJ, Sallu SM

Despite decades of health warnings, nearly half of all tobacco users will die from a smoking-related disease if current trends continue

and (5) either gave results separately for men and women or controlled for gender when these groups were combined