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Here, we employed comparative global metabolomics to demonstrate that metabolism of the antioxidant glutathione (GSH) is inextricably linked to redox-active processes that facilitate melanin production, and that genetic perturbations in GSH biosynthesis affect fungal growth and virulence in a murine model of cryptococcosis

Therefore, this may result in a compromised capability to kill intracellular Mtb, thus further contributing to both infection susceptibility and increased bacterial load (57, 61, 62)

Greco et al [117] randomized 64 patients with UMI and elevated SDF to either treatment with vitamins C and E for 2 months or placebo

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