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PMID: 41 WangTSokerSAtalaASirokyMBAzadzoiKM

Considering APOE is polymorphic in humans, the three alleles form six major genotypes ( APOE2/2, APOE3/3, APOE4/4, APOE2/3, APOE2/4, and APOE3/4 )

As an endogenous ligand of hydroxycarboxylic acid receptor 2 (HCA2), a G-protein-coupled receptor expressed on immune cells, BHB has been shown to modulate inflammatory responses in an experimental model of neuroinflammation [45]