glutathione peroxidase in oxidative stress 4: a new player neurodegeneration? Interplay of antioxidants in Alzheimer's

CB-839 (N-(5-(4-(6-((2-(3-(Trifluoromethoxy)Phenyl)Acetyl)Amino)-3-Pyridazinyl)Butyl)-1,3,4-Thiadiazol-2-yl)-2-Pyridineacetamide) CB-839 is an oral GLS inhibitor developed on the basis of BPTES with a lower IC50 value (0.06 M) and stronger effect compared to BPTES (101)

Oral glutathione sold as a tablet or capsule in India falls under FSSAI's Health Supplements and Nutraceuticals Regulations, which require proper licensing, accurate labelling, and prohibit disease-cure claims

However, once iron metabolism is altered, the iron concentration is increased, which is conducive to ALOX activation

SAR treatment effectively mitigated reactive gliosis, significantly reducing both astroglial and microglial activation within these critical brain regions