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Authors conclude: public health benefits of flavor restrictions may be offset by public health costs of [cigarette smoking]. This is a rigorous paper whose results support the conclusion and look at the big picture, including harmful indirect consequences

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3 Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, Peoples Republic of China *These authors contributed equally to this work Correspondence: Longtao Jin Women and Children Health Hospital of Zhenjiang, 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, Peoples Republic of China Email [email protected] Zhao feng Liang Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, Peoples Republic of China Email [email protected] Abstract: Lung cancer is one of the most common causes of cancer-related deaths worldwide