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Given these limitations, interest has grown in plantderived bioactive compounds for their potential neuroprotective and diseasemodifying effects

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These include specificity of ligand, tissue, cellular localisation and dose, as well as the nature of TAAR1 dimerisation

This disruption affects the inhibitory regulation between neurons, thereby disrupting the excitation/inhibition balance in the brain and promoting the emergence of core symptoms of ASD ( Futhermore, the aristaless-related homeobox (Arx) transcription factor, located on the X chromosome, has been implicated in a wide range of neurological disorders, including intellectual disability and epilepsy, as well as ASD