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Data were analyzed using GraphPad PRISM 7 (GraphPad Software, San Diego, CA, USA) and statistical analysis were performed using one-way ANOVA followed by Tukeys post-hoc test for multiple comparisons

Prostaglandins Leukot Med 9(6):615628

Extracellular vesicles (EVs) are secreted by a variety of cells, including adipocytes (159), and increasing evidence suggests that they may mediate paracrine/endocrine effects (160, 161)

The major components of APS are heteropolysaccharide, neutral polysaccharide, dextran, and acidic polysaccharide, with heteropolysaccharide being the most abundant (Zheng et al., 2020)