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Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress

Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset disease affecting both the upper and lower motor neurons causing their degeneration due to reduced delivery of major trophic molecules, which are crucial regulators of neuronal survival and regeneration

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632 Di-Huang-Yin-Zi effectively decreases ROS and MDA levels in prefrontal cortex, increases the expression of ferroptosis-related markers GPX4 and SLC7A11 and, and decreases iron deposition, thereby improving depressive symptoms and synaptic ultrastructure of cortical regions in post-stroke depressed (PSD) rats, suggesting that Di-Huang-Yin-Zi can reduce the symptoms and enhance function in PSD rats by inhibiting ferroptosis through SLC7A11/GPX4 pathway