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In conditions like AD and PD, we now recognize that brain disorders are not all in the head they involve a constellation of systemic changes, with gut dysbiosis potentially seeding inflammation and protein misfolding long before neurons degenerate

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coli mutant cells (Table 1), cells were transformed with Grx1-roGFP2 coding plasmids, and after expression of the probes for 16 h at 20 C, as mentioned above, cells were harvested, washed twice in HEPES (40 mM, pH 7.4) and adjusted to an OD 600 of 2.0 in HEPES