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As NAD+ decreases, mitochondrial oxidative phosphorylation suffers, which produces less ATP and more reactive oxygen species (ROS)

B Vitamins Can Reduce Body Weight Gain by Increasing Metabolism-related Enzyme Activities in Rats Fed on a High-Fat Diet Supplementation with B vitamins could effectively reduce BW gain and plasma levels of lipids by improving energy metabolism-related enzyme activities in rats, thus possibly providing potential benefits to humans

Dev Biol 229 : 141162 Dominici FP et al

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