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Patil et al., 2024

169 These complexes are essential for autophagosome formation and initiation

BioMed Pharmacother (2006) 60(3):97108

Additionally, O 2 may reduce ferric iron (Fe 3+ ) to ferrous iron (Fe 2+ ) in ironsulfur centers in critical proteins, which may lead to enzyme inactivation and concomitant loss of Fe 2+ from the enzymes, thereby promoting production of H 2 O 2 ( 2 O 2 may then react with Fe 2+ to produce hydroxy radicals (OH ) via the Fenton/HaberWeiss reaction